Celiac Pages

Here’s a quick look at what Thrive was up to last week. Sleep deprivation affects how we interpret emotional cues. The FDA is tired of misleading food labels. Second hand smoke has deadly consequences. Children’s launches a new stem cell website. One mother tells her story of finding out her daughter has celiac disease. Do you know what disease sounds like? Children’s Facebook fan page reaches 100,000 fans. Ray Tye, a noted children’s philanthropist, dies. Michael Agus, MD, reports back from Haiti – twice. Should you take your kids to see Alice in Wonderland? (Source: Thrive, Children's Hospital Boston)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Conclusions - This experience is similar to those described in the world literature. Celiac disease presents the same characteristics independently of the geographic region. We recommend periodic evaluations, from childhood, independent of the duration of the diet. The key is to establish an interval between evaluations.CONTEXTO: A doença celíaca é uma enfermidade multissistêmica e autoimune que pode se manifestar em qualquer idade, em indivíduos geneticamente predispostos. OBJETIVO: Identificação das associações, complicações e causas de morte em pacientes brasileiros após longo período de acompanhamento. MÉTODOS: Foram estudados retrospectivamente 157 pacientes, 23 adolescentes e 134 adultos, 79,6% do sexo feminino e 20,4% do masculino, 75,8% ao diagnóstico e 24,2% em diet...

Authors: Pereira SV, Raba J, Messina GA In the present article, a novel microfluidic immunosensor coupled with electrochemical detection for anti-gliadin IgG antibody quantification is proposed. This device represents an important tool for a fast, simple, sensitive, and automated diagnostic for celiac disease, which is carried out through detection of anti-gliadin IgG antibodies present in human serum samples. Celiac disease (CD) is an autoimmune disease generated by gluten protein fractions called prolamins. This pathology affects about one in 250 people around the world, produces intestinal inflammation, villous atrophy, and crypt hyperplasia, which causes a range of symptoms including altered bowel habits, malnutrition and weight loss. Our immunosensor consists of a Plexiglas device...

Coeliac UK, the national charity for people with coeliac disease, announces it has granted funding for three medical projects totaling £300,000 over three years. 1 in 100 people in the UK has coeliac disease, an autoimmune disease caused by intolerence to gluten but only 1 in 8 or 12.5% of those have been diagnosed. There is no cure and no medication for coeliac disease and the only treatment is a life-long, strict gluten-free diet. Without a gluten-free diet, coeliac disease can lead to infertility, multiple miscarriage, osteoporosis, neurological deficits and bowel cancer... (Source: Health News from Medical News Today)

Coeliac UK, the national charity for people with coeliac disease, announces it has granted funding for three medical projects totaling £300,000 over three years. 1 in 100 people in the UK has coeliac disease, an autoimmune disease caused by intolerence to gluten but only 1 in 8 or 12.5% of those have been diagnosed... (Source: Immune System / Vaccines News From Medical News Today)

Abstract  Poorly differentiated neuroendocrine carcinoma has a poor prognosis, especially when associated with distant metastasis. A 60-year-old man was admitted to a private hospital because of dyspnea at work in 2007. Computed tomography revealed lung infarction and a right adrenal tumor sized 12 cm in diameter that was tightly compressed against the inferior vena cava (IVC). Moreover, multiple lymph node metastases around the celiac axis and a solitary liver metastasis at the lateral segment were observed. Thus, we planned chemotherapy without surgery. We selected a combination therapy of irinotecan (CPT-11) and cisplatin (CDDP) (i.e., IP therapy): administration of CDDP [60 mg/m2 body surface area (BSA)] on day 1 plus CPT-11 (80 mg/m2) BSA on days 1 and 8....

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Conclusion. Familial Mediterranean fever is a rare disorder in Norway but frequent in many Mediterranean countries. Common symptoms are recurrent episodes of abdominal pain, chest pain, joint pain and fever. Treatment with colchicine reduces inflammation and the risk of developing amyloidosis. PMID: 20224617 [PubMed - as supplied by publisher] (Source: Tidsskrift for den Norske Laegeforening)

Conclusion  This case highlights the frequently overlooked association between inflammatory bowel disease and arterial thrombosis. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11845-010-0472-8Authors H. K. Kok, Beaumont Hospital Department of Gastroenterology Dublin 9 IrelandS. Maguire, Beaumont Hospital Department of Gastroenterology Dublin 9 IrelandA. Corr, Beaumont Hospital Department of Gastroenterology Dublin 9 IrelandM. Sadlier, Beaumont Hospital Department of Gastroenterology Dublin 9 IrelandS. Patchett, Beaumont Hospital Department of Gastroenterology Dublin 9 IrelandG. Harewood, Beaumont Hospital Department of Gastroenterology Dublin 9 Ireland Journal Irish Journal of Medical ScienceOnline ISSN 1863-4362Print ISSN 0021-1265 (Source: Irish ...

Abstract  Skin biopsy for epidermal nerve fiber analysis provides an important objective test for the diagnosis of peripheral neuropathy, particularly small fiber sensory neuropathy (SFSN). The determination of epidermal nerve fiber density (ENFD) is reliable, with high diagnostic specificity and good sensitivity. Because of false negatives, biopsy results must be interpreted in conjunction with neurologic findings and laboratory results, including objective tests of sensory and autonomic function. SFSN most commonly is length dependent and is idiopathic in about half the patients. Biopsy of a proximal site (thigh) and a distal site (calf) typically shows greater abnormality of ENFD distally than proximally. More severe abnormality of ENFD in the thigh than in the calf rais...

The Tafts have turned Erica's gluten-free diet into a family affair. Although my husband called her “Smiley,” our happy baby, Erica, was clingy and cranky. For two months, we cleaned up after our 22-month-old as she vomited every day and watched in growing alarm as her tummy grew more and more distended, while her arm and leg muscles atrophied. Her pediatrician thought she had a virus, but she wasn’t getting any better. After four weeks, he referred us to Children’s Hospital Boston, where her gastrointestinal doctor suspected celiac disease. A blood test and endoscopy confirmed it, and the diagnosis brought relief. The disease was causing Erica’s immune system to damage the villi in her small intestine, resulting in her body’s inability to absorb nutrients. The prescripti...

DALLAS, March 10 (UPI) -- Relatively few grains have the protein indigestible to those with celiac disease and psoriasis and some grains are safe for them to eat, a U.S. researcher says. (Source: Health News - UPI.com)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Authors: Lujan HL, Palani G, Peduzzi J, Dicarlo SE Individuals with spinal cord injuries above thoracic level 6 (T6) experience episodic bouts of life threatening hypertension as part of a condition termed autonomic dysreflexia (AD). The paroxysmal hypertension can be caused by a painful stimulus below the level of the injury. Targeted ablation of mesenteric projecting sympathetic neurons may reduce the severity of AD by reducing sympathetic activity. Therefore, cholera toxin B subunit (CTB) conjugated to saporin (SAP, a ribosomal inactivating protein that binds to and inactivates ribosomes) was injected into the celiac ganglion to test the hypothesis that targeted ablation of mesenteric projecting sympathetic neurons reduces the pressor response to pain in conscious spinal cord transe...

Canadian researchers are testing a new drug for patients who suffer from a chronic digestive disorder called celiac disease, which appears to be afflicting a growing number of people. (Source: CTV Health)

Conclusions: Expression and synthesis of fls485 are found in surface lining epithelia of normal human intestinal mucosa and deriving epithelial cell lines. An interdependence of enterocyte differentiation along the crypt-villus axis and fls485 chaperone activity might be possible. (Source: BMC Gastroenterology)

When celiac disease is diagnosed in adulthood, mucosal damage might never completely resolve, even on a gluten-free diet, according to a February 9th online report in The American Journal of Gastroenterology. Reuters Health Information (Source: Medscape Gastroenterology Headlines)

Researchers have developed a new instrument specifically for measuring quality of life in patients with celiac disease. (Source: MedWire News - Gastroenterology)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

(Source: Gut)

Conclusions Endocytic segregation of gliadin peptide AA 31–49 seems to be a constitutive process. It explains why this peptide cannot stimulate gluten-sensitive T cells. Presentation of gliadin peptides by HLA-DR proteins via late endosomes within enterocytes might induce a tolerogenic effect and constitutes a potentially promising therapeutic approach for induction of tolerance towards gliadin. (Source: Gut)

Conclusion p31–43 accumulation in lysosomes leads to epithelial activation via the ROS–TG2 axis. TG2 works as a rheostat of ubiquitination and proteasome degradation and drives inflammation via PPAR downregulation. (Source: Gut)

Recent research findings indicate a possible connection between virus infections, the immune system and the onset of gluten intolerance, also known as celiac disease. (Source: ScienceDaily Headlines)