Celiac Pages

is a daily summary made from the selected links I post on Twitter. It is in bullet-point format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day: Procalcitonin-guided strategy to treat suspected bacterial infections reduced antibiotic exposure in ICU by 2.7 days http://goo.gl/mws0 Both low and high HbA1c associated with increased mortality in diabetes. Guidelines for minimum HbA1c value may be needed. Survival as a function of HbA1c in type 2 diabetes: U-shaped association, with the lowest hazard ratio at HbA1c of 7·5% http://goo.gl/Lywx No sedation vs. interrupted sedation in mechanical ventilation was associated with fewer days on the ventilator. Lancet http://goo.gl/OYoe One Bowl = 2 Servings. Puzzled? F.D.A. Weighs Update to St...

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Discussion Failure to Thrive (FTT) is defined as persistent weight below the 3rd percentile for age in infants and young children. The associated terms “Failure to gain weight” (FGW) or “Lack of Normal Physiologic Growth and Development” are more precise, especially for children who are not below the 3rd percentile but are losing weight over time and/or crossing percentile lines on their growth curve. For general growth parameters see How Do I Calculate Mid-Parental Height and Other Growth Parameters? About 70-80% of FTT cases have psychosocial problems that are associated with the FTT or the primary cause of the FTT. Children of older ages may also have FTT such as those with psychosocial dwarfism or eating disorders. Children with FTT have a wide range of appearan...

Collagenous sprue - a rare disorder with features of gluten enteropathy - is not always a complication of celiac disease, according to new research from the Mayo Clinic. Reuters Health Information (Source: Medscape Gastroenterology Headlines)

The Roman Catholic Church needs to do more to accommodate people with celiac disease who can't eat gluten hosts offered during mass, says a Canadian Celiac Association official. (Source: CBC | Health)

Abstract  Diagnosis and therapy of osteoporosis associated with gastrointestinal diseases is a remarkable problem. Osteoporosis is most common in celiac disease, Crohn’s disease, chronic liver disease, and in postgastrectomy patients. Protocols regarding prevention, diagnosis and therapy are based on results gained from patients with osteoporosis in the general population. This review aims to summarize the special aspects and most important clinical data regarding the bone loss associated with gastrointestinal diseases. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12018-010-9069-zAuthors Pál Miheller, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest HungaryPéter L. Lakatos, Semmelweis University 1st Department of...

Authors: Picarelli A, Libanori V, De Nitto D, Saponara A, Di Tola M, Donato G Anti-endomysial and anti-transglutaminase antibodies can be produced in vitro by the intestinal mucosa of celiac disease (CD) patients in clinical remission, when the culture is performed in the presence of gliadin peptides. Our aim was to use this organ culture system as a means to detect the pathognomonic antibodies of celiac disease (CD) in the culture supernatants. Organ culture was performed in the presence of three different activators to evaluate which one induced the strongest antibody response in intestinal mucosa from patients in clinical remission of CD. Our data confirm the high efficiency of synthetic peptide 31-43 as a specific immunological activator in CD and demonstrate its capability to stim...

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Dr. Sheila Crowe explores the links between celiac disease and infertility, miscarriages and low-birth-weight babies. (Source: NYT > Health)

TV DOCTOR Chris Steele yesterday handed in a petition to Downing Street calling on the government to help improve the diagnosis of coeliac disease, a condition he recently fo (Source: Scotsman.com News - Health)

Kids with celiac disease need a gluten-free diet, but celiac disease isn't diagnosed in half of kids who have it. Asking 5 simple questions helps, a Danish study finds. (Source: WebMD Health)

We present a case in which the typical imaging appearances of coalescent peripheral hepatic masses with capsular retraction contributed to the diagnosis. A positron emission tomography-CT (PET-CT) procedure was performed in staging the disease with a strong suspicion of coeliac nodal involvement confirmed after laparotomy and histological analysis. Our case is unique because of the rarity of the disease, the young age of the child, and proven nodal metastases at initial diagnosis. The use of PET-CT allows better staging at initial diagnosis and thus better management with improved follow-up in these patients. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00247-009-1532-yAuthors David Da Ines, CHU Clermont-Ferrand Service de Radiologie et Imagerie Médicale, Hôtel D...

We report the case of a successful multivisceral transplant in which both donor and recipient presented aberrant anatomy of the celiac-mesenteric axis requiring five separate arterial anastomoses to reconstruct the blood inflow to the graft. (Source: American Journal of Transplantation)

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Digestion 2010;81:231–234 (DOI:10.1159/000269810) (Source: Digestion)

This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies.We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies.We detected significant associations of rs6822844 with SLE (P = 0.00...

EndoscopyDOI: 10.1055/s-0029-1243838 Celiac disease is a gluten-induced enteropathy whose diagnosis is based on histological evidence of villous atrophy. The diagnosis may be difficult if the orientation of histological sections is other than optimal. During upper gastrointestinal endoscopy we studied in vivo duodenal mucosa in patients with celiac disease using endocytoscopy, a novel diagnostic technique allowing in vivo real-time visualization of mucosa under × 450 magnification.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Endoscopy)

Title: Diabetes Treatment
Category: Diseases and Conditions
Created: 12/5/2006
Last Editorial Review: 1/26/2010

What is the long term clinical significance of anti-thyroid antibodies detected during surveillance of patients with celiac disease? In this issue of The Journal, Cassio et al have shown that despite a high prevalence of positive screening tests for autoimmune thyroiditis, the rate of development of clinical hypothyroidism is low. The development of autoimmune markers did not correlate with gluten ingested. In fact, many of the subjects developed thyroid antibodies while adhering to a gluten-free diet. (Source: The Journal of Pediatrics)

Title: Rheumatoid Arthritis
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 1/25/2010

Conclusion: This is one of the largest studies to date to quantify the risk of diagnosis of coexisting autoimmune diseases in more than 3000 index cases with well-characterized Graves' disease or Hashimoto's thyroiditis. These risks highlight the importance of screening for other autoimmune diagnoses if subjects with autoimmune thyroid disease present with new or nonspecific symptoms. (Source: The American Journal of Medicine)

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Authors: Jüse U, van de Wal Y, Koning F, Sollid LM, Fleckenstein B HLA-DQ2 (DQA1*0501/DQB1*0201) is associated with several immune disorders including celiac disease which is caused by an inappropriate T-cell response to gluten. Interference with peptide presentation by HLA-DQ2, for example by the use of peptide blockers, is a possible treatment strategy for such HLA associated disorders. A successful implementation of this strategy will depend on the identification of ligands that bind much better to HLA-DQ2 than the disease related epitopes. We have used a positional scanning nonapeptide library to determine the optimal amino acids for each position of the HLA-DQ2 binding frame. By combining the optimal residues in each position, we were able to design high affinity binders to H...

Authors: Freeman HJ Collagenous sprue has traditionally been defined as a small intestinal mucosal disorder characterized by persistent diarrhea, severe malabsorption with multiple nutrient deficiencies and progressive weight loss. Pathologically, a severe to variably severe "flattened" mucosal biopsy lesion with distinctive sub-epithelial deposits in the lamina propria region is detected. Histochemical stains and ultrastructural studies have confirmed that these deposits contain collagens. Often, an initial diagnosis of celiac disease is considered but no continued response to treatment with a gluten-free diet occurs. Recent reports indicate an intimate relationship between collagenous sprue and celiac disease, sometimes with concomitant T-cell enteropathy. In addition, permanent disa...